Archive

Monthly Archives: December 2012

Disappointing results here for novel anticoagulants in patients with mechanical heart valves

Old CardioBrief

Boehringer Ingelheim today announced that it had discontinued a phase 2 trial of its anticoagulant drug dabigatran (Pradaxa) in patients with mechanical heart valves. As reported here in October, the company had previously terminated one arm of the study after an interim review of the data by the trial’s Data Safety Monitoring Board

The RE-ALIGN trial was an open-label, 12-week randomized comparison of warfarin and dabigatran in 400 patients who received a mechanical valve. The first arm randomized patients during their initial hospital stay. The second arm randomized patients more than 3 months after their surgery.

Despite the recent advent of novel oral anticoagulants, the much-maligned warfarin remains the only current option available for patients who have received a mechanical valve. Now the first trial to explore this indication for one of the newer oral anticoagulants has been stopped.

In October Boehringer told members of its speakers bureau that the post-surgery arm of…

View original post 1,786 more words

Dear Will,

Thank you for registering to attend ACC.13, March 9-11 in San Francisco.

Our records indicate that you signed up to participate in the 5K CardioSource Fun Run event, scheduled for Monday, March 11, 2013. We are writing to inform you that this event has been cancelled due to liability issues caused by the change in Daylight Savings Time while we are in San Francisco which has impacted our ability to effectively manage the run.  We apologize for any inconvenience, and look forward to welcoming you to ACC.13.

Sincerely,

The ACC Registration Team